It's usually a good idea to look for an alignment that allows your most often inhabited spaces facing the northern light.
One idea is that those spaces will hold the warmth into the evening thereby reducing heating costs. Of course this means you're likely to need some sort of awning or shading during the warmer months.
Another reason to harness the northern light is that you'll save on lighting bills (should you have enough windows of course). If you do end up with alot of light and heat, try and get some 'casement' windows too. They hinge outwards and are great for catching any cooling breezes.